By Farshad Darvishi Harzevili

Due to its skill to degrade hydrophobic substrates hugely successfully, the non-conventional yeast Yarrowia lipolytica deals numerous functions within the nutrition, feed, pharmaceutical, and wonderful chemistry industries, in addition to in environmental security contexts reminiscent of waste therapy and bioremediation.

The yeast breaks down hydrophobic substrates reminiscent of n-alkanes, fatty acids, fat, and oils, yielding invaluable biotechnological items comparable to natural acids, extracellular enzymes, aroma compounds, bioemulsifiers, polyols, single-cell proteins, and single-cell oils. extra, Y. lipolytica is a good platform for the construction of varied heterologous proteins; greater than 100 heterologous proteins – together with these of viruses, micro organism and fungi, in addition to plant, animal and human proteins – have already been produced in Y. lipolytica. considering that its genome has been sequenced, it really is now attainable to take advantage of new recombinant know-how and metabolic engineering for you to enhance the metabolic pathways fascinated with the construction of fascinating metabolites and products.

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Extra info for Biotechnological Applications of the Yeast Yarrowia lipolytica

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2. Therefore, immobilization and drying of the extracellular lipase from Y. lipolytica are valuable methods that lead to decreased cost of utilization, preservation, and transport. 2 Proteases The Y. lipolytica secretes acidic and alkaline proteases depending on the pH of the growth medium. Proteases production is also controlled by carbon, nitrogen, and sulfur starvation (Ogrydziak and Mortimer 1977). Both proteases are similarly induced at the end of the exponential phase on complex media containing proteins, whereas the type of protease synthesized is strictly dictated by ambient pH (Glover et al.

2008b). 22 Yarrowia lipolytica in Biotechnological Applications Both spray-drying and freeze-drying as dehydration methods are used to produce a stable lipase powder. Fickers et al. produced large-scale lipase with a lipolytic activity of approximately 1,100 U/mL in a 2,000-L bioreactor after 53 h of fermentation, and then added 12 % of milk powder and 3 % of gum arabic as additives to semi-purified and concentrated lipase solution before spray-drying, which led to production of a stable powder.

1988; Ogrydziak 1988). 8, while this host cannot degrade the proteins in YPD (Madzak et al. 2000). 1 Extracellular Enzymes Production 25 Y. lipolytica proteases are of interest for biotechnological applications. However, unlike lipase, there are little or no reports on large-scale production and downstream processes of Y. lipolytica proteases till now. 3 Phosphatases Several phosphatase activities have been found in the Y. lipolytica. A cell wallbound acid phosphatase activity is induced when Y.

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